Porifera have long been a reservoir for the discovery of bioactive compounds and drug discovery. Marine natural\nproducts are able to interact with many specific targets within the cell and are finding increasing use as probes to interrogate\nbiological systems as part of chemical genomics and related research. The alarming increase in the global cancer death toll has\nfueled the quest for new effective anti-tumor drugs thorough in-silico screening of both terrestrial and marine organisms. Drug\ndiscovery has been carried out by computational methods using Schrodinger software, many poses of docked complex shows\ngood interactions and binding interface were identified by Ligplot. Further studies on in-vitro and in-vivo were required to\nconfirm their inhibitor effect on breast cancer. Docking studies gives optimism for the isolation of new bioactive compounds\nfrom a relatively unexplored source.
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